An inherited mutation is likely the link between exploding chromosomes and some aggressive types of cancer. Looking at the complete genome sequence of childhood brain tumors, scientists found one or two chromosomes in each cell had countless parts in the wrong order, missing or repeated. Researchers found these tell-tale signs of chromosome explosion, or chromothripsis, in samples from patients who have a mutation in the TP53 gene, but not in patients with normal TP53. Cancer treatment often ...
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